.. GraphPCA documentation master file, created by sphinx-quickstart on Wed Apr 3 19:25:25 2024. You can adapt this file completely to your liking, but it should at least contain the root `toctree` directive. Welcome to GraphPCA's documentation! ==================================== GraphPCA – a fast and interpretable dimension reduction algorithm for spatial transcriptomics data. ===================================================================================================== .. toctree:: :maxdepth: 1 :caption: Contents: Installation Tutorial1_DLPFC Tutorial2_mPFC Tutorial3_Integration Tutorial4_MSI .. image:: ../figures/workflow.png :width: 1400 Overview ======== GraphPCA is a novel graph-constrained, interpretable, and quasi-linear dimension-reduction method tailored for spatial transcriptomic data. It leverages the strengths of graphical regularization and Principal Component Analysis (PCA) to extract low-dimensional embeddings of spatial transcriptomes that integrate location information in linear time complexity. The substantial power boost enabled by GraphPCA fertilizes various downstream tasks of spatial transcriptomics data analyses and provides more precise insights into transcriptomic and cellular landscapes of complex tissues.